pysam by pysam-developers

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

created at Feb. 5, 2014, 8:38 p.m.

Cython

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GitHub
cyvcf2 by brentp

cython + htslib == fast VCF and BCF processing

created at Aug. 12, 2015, 2:30 p.m.

Cython

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GitHub